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Jul 2011;141(7):1355-61

GABA is an inhibitory neurotransmitter that relies on vitamin B6 as a cofactor for biosynthesis.[ref] Related article: GABA: Genetics, Anxiety, and Immune Response Genetic mutations in the PDXK gene, which converts pyridoxine from food into the active P5P form, can cause peripheral polyneuropathy.[ref] Thus, a safer option for someone with peripheral neuropathy may be to supplement with the active P5P form of vitamin B6

Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis