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Despite significant advances in cancer therapeutics, major clinical challenges persist, such as multi-drug resistance, systemic toxicity, and high rates of recurrence, all of which contribute to the substantial burden of cancer care (9)

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

Xue M, Fu M, Zhang M, Xu C, Meng Y, Jiang N, et al

The typical dosage involves: Loading phase: 20g daily for 5-7 days (split into 4 doses) Maintenance: 3-5g daily or 0.1g per kg of body weight Timing: Post-workout or with carbohydrates for better uptake Creatine supplements work best when taken consistently

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Finally, we employed our computational pipeline to systematically assess how ( R )-2HG accumulation affects nitrogen metabolism (Extended Data Fig