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Description

It identifies and eliminates foreign pathogens, while monitoring and maintaining internal homeostasis

We propose that the altered liver metabolism in BWS liver is a major contributor to hepatomegaly and cancer predisposition to hepatoblastoma, based on the presence of ROS-related DNA damage

It was demonstrated that 10% weight loss at PDAC diagnosis compared to weight prior to diabetes onset had a higher adjusted odds ratio in PDAC-associated diabetes individuals compared to T2D (93), while age-adjusted hazard risk for PDAC-associated diabetes increased with increasing weight loss in NOD individuals compared to T2D (26)

The genes encoding DDB1 , CULLIN4A , RBX1 , DET1 , DDA1 , c-Jun , STK40 , ETS2 , Ube2e family ( Ube2e1 ~ 3 ), Ube2d3, Uba3, UBC12, APPBP1 and NEDD8 were amplified from cDNA by PCR and subcloned into pCAG vectors with different tags, respectively