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Oral : administration by mouth Intrathecal : infusion into the fluid surrounding the brain and spinal cord Intra-arterial (IA) : injection into an artery Intraperitoneal (IP) : injection into the abdominal cavity Intravesical : administration directly into the urinary bladder through a catheter Intramuscular : injection into a muscle Topical : application to the skin Subcutaneous : injection under the skin 4 Chemotherapy Dose Optimization Conventional chemotherapy regimens are typically calibrated to deliver the maximum tolerable dose of cytotoxic drugs (Baszkowsky 2012

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Consistent with these findings, Trx1 also suppresses autophagy via the TXNIP/mTOR pathway

Eur J Endocrinol (2016) 175(2):G1G34

Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Huynh KD, Javonillo DI, Tran KM, Phan J, Jiang S, Kramr EA, Nuez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM

To remove tough ends, common advice is to snap the stalks at their natural breaking point