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doi: 10.1186/s13046-020-01669-w 94 ChenC-LHsuS-CAnnDKYenYKungH-J

L-Glutamate is the most abundant free amino acid in the brain , where it contributes to: Synaptic signaling Learning and memory Formation of the cytoskeleton Proline synthesis (for collagen and connective tissue) (Plitman et al., 2014, Biological Psychiatry ) Most of the glutamic acid in the brain is synthesized from L-glutamine and Krebs Cycle intermediates