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10.1136/bmj.2.5806.131 [DOI] [PMC free article] [PubMed] [Google Scholar] 32

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One important biosynthetic route of NMN is the conjugation of nicotinamide with phosphoribosyl pyrophosphate (PRPP), catalyzed by nicotinamide phosphoribosyltransferase (NAMPT) 44

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Kato et al., Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

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The mean SEM of the ratio of each enzyme mRNA to the level of the 18S rRNA signal is shown as an arbitrary unit

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Year-round use is not recommended due to receptor desensitization and potential for diminishing returns

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