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4,5 GM-CSF is produced by both hematopoietic (eg, T cells, B cells, macrophages, monocytes) and some viscerosomatic cells (type II alveolar epithelial cells, endothelial cells, fibroblasts) and can activate cells through the dimeric GM-CSF receptor expressed primarily on monocytes and macrophages but also on dendritic cells and other cells of the innate immune system (Figure 2A)

7.1 CHAC1 in response to chemotherapy CHAC1 upregulation is frequently seen in tumors following receiving chemotherapy or immunotherapy

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