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Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

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It is also involved in immune function, metabolism, tissue building and repair, sperm cell formation, and certain enzyme functions

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Anti-apoptosis and autophagy are among the main ways to maintain the malignant proliferation of MDR cells, so the therapeutic effect of phenformin in MDR cancer is worthy of further exploration