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638 Saikosaponin B2 alleviates ER stress by regulating intracellular Ca 2+ levels, reducing lipid peroxidation and intracellular Fe 2+ content, and inhibiting ferroptosis in a GPX4-dependent manner, thereby improving CUMS-induced depressive behavior

GBA has also been one of the targets in AAV-mediated gene therapies

First-in-human trail of M9140, an anti-CEACAM5 antibody-drug conjugate with Exatecan payload, in patients with metastatic colorectal cancer

Lee J, Roh J-L

topical works locally with a strong published safety record

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