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A new drug is presently under investigation in clinical trials: bis-choline-tetrathiomolybdate (TTM)

doi: 10.1186/s13073-016-0361-5 99 NakayamaNNakayamaKShamimaYIshikawaMKatagiriAIidaKet al

Angiotensin IV (Val 1 -Tyr 2 -Ile 3 -His 4 -Pro 5 -Phe 6 ) is an endogenous hexapeptide fragment of the renin-angiotensin system, historically considered a metabolite of angiotensin II but subsequently shown to have independent procognitive activity in rodent models

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Shaking creates mechanical stress and shearing forces that can break the fragile peptide bonds, rendering it useless