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This manuscript abides by the ARRIVE guidelines for the reporting of animal experiments

[58]The nature of this interaction is not clear

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Later studies built on these findings by showing the ability of CAR T reg cells to prevent and/or ameliorate disease in other mouse models of colitis 99 , colitis-associated cancer 100 , and experimental autoimmune encephalomyelitis 101

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The bioactive compounds within them can regulate inflammatory pathways by suppressing the production of pro-inflammatory cytokines and enzymes, such as tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) (11, 12)