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CDRs complementarity determining regions Human antibodies can be made by several different ways, including by use of human immunoglobulin expression libraries (Stratagene Corp., La Jo 11a, California) to produce fragments of human antibodies (VH, VL, Fv, Fd, Fab, or (Fab')2, and using these fragments to construct whole human antibodies using techniques similar to those for producing chimeric antibodies

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Insufficient in-depth analysis of the disulfidptosis mechanism has led many existing studies to focus on superficial phenomena, with inadequate systematic research on its regulatory networks, upstream/downstream signaling pathways, and specific intracellular targets (83)

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