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Sulfasalazine (SAS) also acts on System X C - to inhibit the uptake of cystine [149], causing chronic depletion of glutathione in cells, thereby destroying the redox defense of cells, hindering tumor growth, and inducing tumors ferroptosis [149,150,151,152,153]

STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains

Reilly TP, Mechanistic JC

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Reconstitute with sterile bacteriostatic water or appropriate laboratory buffer Add solvent slowly along the vial wall to minimize foaming Gently swirl until the peptide is dissolved Store reconstituted solutions at 3646 F (28 C) Prepare aliquots where appropriate to reduce freezethaw cycles Careful reconstitution supports peptide stability and preserves functional integrity in experimental systems

We interpret the first phase as the glutathionylation of the PfGrx moiety that became detectable for the nearby fraction of fused roGFP2 molecules (Fig