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Indeed, when nicotine is administered concurrently with a CYP2A6 inhibitor of unknown strength, the substrate metabolism will be reduced, resulting in increasing serum concentrations and heightened risk, incidence, and/or severity of ADRs

The RIC regimen included fludarabine 30 mg/m 2 /day on day 6 to day 2, intravenous busulfan 3.2 mg/kg/day on either 1-2 days on days -3 and -2, and Cy (14.5 mg/kg) on day 6 and day 5

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Similarly, luteolin-4-O-glucoside was demonstrated to reduce foot swelling in rats by lowering serum pro-inflammatory cytokines in MSU crystal-induced gouty arthritis (31)