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Proteostasis resilience: a new framework for disease intervention Across disease systems, one recurring theme emerges: the difference between cellular survival and failure is determined not only by the existence of proteostasis pathways but also by their resilience capacity and their ability to respond robustly, flexibly, and coordinately

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In much the same way that your body needs consistent replenishment of food and water, it needs Vitamin C to survive and thrive

Such functions include transport of long-chain fatty acids from the cytoplasm to the mitochondrial matrix, regulation of acetyl-CoA/CoA, control of inter-organellar acyl traffic, and protection against oxidative stress

304 p53 colocalizes with apoptotic or nonproliferating macrophages at atherosclerotic sites