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Warnings: Due to the risk of dofetilide causing arrhythmia, patients are typically hospitalized for 3 days for monitoring

107 On May 11, 2021, this variant was designated as VOC by WHO and labeled Delta ( VOC Delta was a worldwide circulating VOC after VOC Alpha and was detected by at least 169 countries ( There were ten mutations in the S protein of Delta variant: T19R (found in 98.3% reported delta strains), T95I (38.3%), G142D (66.1%), E156G (92.1%), Del157/158 (92.2%), L452R (96.9%), T478K (97.2%), D614G (99.3%), P681R (99.2%), D950N (95.3%) ( G142D and E156G are located in the N3 loop, which NTD antibodies could target, 129 thus may affect the neutralization activity of NTD antibodies

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The dose of the drug is calculated for each patient individually

Reitman recommends baseline blood work to confirm deficiency and rule out other causes of fatigue

A., da Silva, R