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C., et al

10.1038/ng.2982 39 SpragueB

Bibliography Berry CG

Key signs and symptoms include pitting edema (negative Stemmers sign) around ankles and feet, pruritus, restless legs, and nocturnal cramps, which often improve with limb elevation

The strongest evidence showing H2O2 itself activates transcription factor is provided by the study on yeast transcription factor YAP1 (Coleman et al., 1999)