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J Clin Endocrinol Metab 91, 3494-8 (2006)

HK2 limits RIPK1-driven liver ischemia-reperfusion injury Activated RIPK1 mediates caspase-8-dependent apoptosis upon stimulation of tumor necrosis factor receptor 1 (TNFR1) by TNF, this apoptosis process plays an important role in liver I/R injury 55,56

Finally, GH was shown to increase the renal synthesis of the antiaging hormone Klotho in healthy subjects and patients with CKD, indicating that GH treatment may have beneficial effects on the cardiovascular system