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Furthermore, IS and IAA, as typical AHR ligands, can bind to cytoplasmic AHR, and the IS/AHR complex translocates to the nucleus, where it binds to AHR nuclear translocation via heat shock protein 90 exchange and serves as a transcriptional activator by binding to specific xenobiotic response elements in promoter regions of enzymes that generate ROS [96]

Lv N, Jia L, Liu F, et al

doi:10.1016/j.abb.2008.02.008

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Mullins, R., Reiter, D

Dehydration tolerance One of the most critical physiological stressors for amphibians living in terrestrial environments is dehydration, which develops due to the loss of body water content