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2013/122,506 and 2013/0296402

From dysbiosis to neurodegenerative diseases through different communication pathways: An overview

O.OnadekoB.TinuadeA

It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances ( Subclinical B12 deficiency, however, is far more prevalent, affecting up to 26% of the general population

Together, these findings suggest that MCO's such as CueO help protect bacteria from copper stress by controlling copper ion oxidation states in oxic environments