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To address sleep disturbances, melatonin is frequently employed

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J Clin Endocrinol Metab

However, reduced or impaired immune function is a source of acute medical distress in mitochondrial disease, and infections are a major cause of morbidity and mortality in these patients

For instance, a gemcitabine/carboplatin regimen was only considered as chemotherapy based on gemcitabine rather than platinum