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One such pathway involves the rapid stimulation of phospholipase C (PLC), which facilitates inositol trisphosphate-mediated calcium release from intracellular stores

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10.1016/j.maturitas.2011.12.017 [DOI] [PubMed] [Google Scholar] 94.Chmielewski P et al

Specifically, BMP15 and GDF9 secreted by oocytes normally activate the TGF signaling pathway, promoting granulosa cell proliferation, differentiation, and functional maintenance, thereby supporting oocyte maturation and normal follicular development

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The most common strategy to improve curcumin's poor pharmacokinetic profile involves combining it with piperine, a natural alkaloid found in black pepper (Piper nigrum), which effectively inhibits the glucuronidation process [512]