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H 2 S can form naturally underground as organic matter decomposes, but is most often produced by sulfate-reducing bacteria that convert sulfates in water into hydrogen sulfide

Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication

Nigam et al

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Although they can be given safely as frequently as once a week, we recommend once every 2 to 4 weeks