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This article reviews the evidence that NRF2 activation declines with ageing

We observed that the decrease in respiratory chain function upon NNT knockdown was associated with an increase in survival under cystine deprivation (Fig

Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]

Wang Y., Ren Z., Tao D., Tilwalli S., Goswami R., Balabanov R., Glia 2010, 58, 195

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