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cAMP post-transcriptionally diminishes the abundance of adrenodoxin reductase mRNA

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This suggests that under T2 stressed conditions, increases in SLC7A11 activity help maintain intracellular redox balance (Figure 3G)

HIF-1 activation leads to the transcription of genes involved in angiogenesis, glycolysis, and cell survival, facilitating tumor growth and adaptation to hypoxic conditions [108]

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This applies also to acute complications of diabetes - ketoacidosis, hyperglycaemic-hypermolar state, recurrent and severe hypoglycaemic episodes