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Description

Most anti-neoplastic drugs, which are often hydrophilic and large, cannot cross the BBB efficiently due to their size and polarity (87, 88)

& Carpinella, M

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

Also, the framework assumes steady-state metabolism and constant photon input, thereby limiting its ability to represent dynamic temporal metabolic reprogramming

Methods Enzymol 186:421431 Duan W, Lee J, Guo Z, Mattson MP (2001) Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury