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Heterologous expression studies further demonstrated that OsHMA4 localizes to the tonoplast and enhances vacuolar Cu sequestration

This is in sharp contrast to GSH, which can only stay in the blood, truly achieving an efficacy upgrade from blood to cells

Iron chelators such as deferoxamine and deferiprone, while effective in mitigating epithelial ferroptotic injury in preclinical models, carry the risk of systemic iron depletion and may exacerbate anemia-a condition already prevalent among IPF patients due to chronic inflammation and reduced erythropoiesis (178)

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Selenium is an oxidizing agent, which easily reacts with the sulfhydryl group in the active center of the viral protein disulfide isomerase, thus inactivating it

The initial characterization of hGMSCs was conducted through cytofluorimetric analysis and differentiation assays