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This is because the coordination state of the copper ions in the GHK-Cu and the tripeptide is crucial to its efficacy, and acidic substances can easily dissociate the copper ions in the complex, which will reduce the activity of superoxide dismutase

Chen L, Yi X, Goswami S, Ahn YH, Roybal JD, Yang Y

the control only reached 35 % When they blocked VEGFR2 (with the selective inhibitor SU5416), all of these effects disappeared Why it matters: The last point is what holds the study together