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Description

The pharmacological inhibitor of myoferlin can reduce the abundance of System X c - and GPX4 which trigger mitophagy and ROS accumulation culminating with lipid peroxidation and ferroptosis (Rademaker et al., 2022)

Gtz, J

2012(8):CD007653

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10.1007/s10557-022-07323-1 180 ZhangH.LinY.MaY.ZhangJ.WangC.ZhangH

We observed a significant upregulation in IL-10 levels and significant downregulation of TNF-, IL-6, and IL-1 in GGC-treated cells, suggestive of the beneficial effects of GGC against oligomeric A 40 -induced neuroinflammatory response