glutathione protein folding What is Glutathione? – GoldBio Powerful Antioxidant Found To Play

Wild-type enzyme and K105X mutants tended to have infinite true k cat and K m values for extrapolated infinite substrate concentrations, suggesting that the enzymes are neither saturated by GSSCys nor GSH (Supplementary Fig

doi: 10.1016/j.immuni.2017.04.016 137 TabasIBornfeldtKE

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FarmakisDPorterJTaherADomenica CappelliniMAngastiniotisMEleftheriouA

A T594V mutation that would interfere on the hook-shaped conformation reduced the catalytic efficiency ( K cat/ K m) by 13%, from 12.07 M min to 10.45 M min (Fig 1L- 1M