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Moreover, ChiC and ChiE contain conserved cysteines that form a reversible disulfide bond, suggesting redox-sensitive regulation of ligand interaction, as confirmed by structural data and the Ellman assay (Table S4)

Substance P Promotes Leukocyte Recruitment and Activation While the CNS is extensively protected by the blood-brain barrier, inflammation within the brain leads to the infiltration of peripheral macrophages, dendritic cells, T cells and other immune responders (Hickey, 1999