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Organochlorine insecticides in substantia nigra in Parkinsons disease

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Another priority is the establishment of preclinical models that better simulate the heterogeneity of PD, so PLGA-based nanoparticles could be tested under physiologically relevant conditions 150

The selective depletion of GSH in this organelle can sensitize hepatocytes to the oxidative effects of cytokines such as tumor necrosis factor (TNF) [85]