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Heavy metal stress (Cd and/or Pb) in plants results in the overproduction of ROS, which is regulated by antioxidant defense systems that include non-enzymatic antioxidants including GSH, enzymatic antioxidants (SOD, APX, CAT, POX, and GR), carotenoids, -TOC, and proline (Semida et al., 2018)

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( d ) Cells were treated with the IDH1 (IDH1i) and olaparib (Olap) or cisplatin (Cis) alone or combined (n = 4 technical replicates representative from independent experiments)