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or who had received more than 30 Gy of thoracic radiation within the prior 26 weeks were ineligible

The absence of TNX protein suggested recessive inheritance, a concept bolstered by the fact that the index patients clinically normal parents and two siblings each share an extended TNX/CYP21 haplotype with the proband

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10 The biomechanical properties of the spine are compromised, leading to spinal instability, back pain and other clinical symptoms

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