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18,19 Although heavy metal toxicities due to lead, mercury, and cadmium are generally considered rare in mainstream medicine, less well-recognized is that chronic accumulation that may not achieve classical acute toxicity thresholds may nevertheless contribute to adverse health effects

doi: 10.1016/j.cell.2017.05.018 159 KhanN.SyedD

10.1038/cmi.2011.3 62 SuiJ.DemingM.RockxB.LiddingtonR

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demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)

Supply costs typically represent 10% to 20% of the treatment price, and nurse staffing costs are predictable and scalable