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One major mode of immunosuppression is the secretion of soluble ligands that inhibit anti-tumor immune cells

ABCB7 exhibits an early pre-hydrolytic state with a sufficiently large cavity to accommodate the substrate prior to transitioning to an outward-facing release conformation

Hays KE, Pfaffinger JM, Ryznar R

Burtscher J, Moraud EM, Malatesta D, Millet GP, Bally JF, Patoz A

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For example, inhibition of ATR by M6620 significantly induces lung cancer cells harboring more than two micronuclei, eliciting cGAS-micronuclei interacting to activate immune responses and partially enhance the responses to immunotherapy [100]