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High-protein intake is particularly important during GLP-1-mediated weight loss because it preserves lean muscle mass, enhances satiety (complementing the drug's effects), and stimulates endogenous PYY release for additional appetite control

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Isatuximab causes preferential depletion of Tregs by causing apoptosis, inhibiting cell proliferation, and relieving conventional T cells from suppression, thereby inducing immunomodulation in MM patients (Figure 4) [80, 81]