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Andrographolide-LA-1 (Figure 6E), a compound synthesized through the esterification of andrographolide and ALA, was proposed to be a major transcription factor that significantly reduces the inflammatory response in inflammatory bowel disease [91]

Critically, immunoregulatory pathways are compromised

Together, these ingredients help maintain healthy antioxidant activity, support cellular repair, and promote normal detoxification pathways

However, rapamycin has limited utility because it lacks specificity, and acts on other essential pathways involved in immunosuppression, and thus is not a viable drug candidate for PD where long-term treatment would be necessary

10.1016/j.chemphyslip.2011.04.005 10

doi:10.1016/j.pnpbp.2010.08.026, PubMed PMID: 20828592 Vialou V, Feng J, Robison AJ, Nestler EJ (2013) Epigenetic mechanisms of depression and antidepressant action