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If a rash is still spreading or worsening past 48 hours, contact your prescriber that timeline distinguishes a normal local reaction from one that needs evaluation

The genes studied are involved in regulation of the NFB pathway ( TLR2 , TLR4 , TLR5 , TLR9 , LY96 , CD14 , MAP3K14 , SUMO4 , NFKBIA and NFKB1 ), TNF- signaling ( TNFA , TNFRSF1A and TNFAIP3 ), cytokines regulated by NFB ( IL1B , IL1RN , IL6 , IL10 , IL17A and IFNG ) and other genes involved in regulation of inflammation ( IL4R , IL6R , IL23R , TGFB1 , PTPN22 , PPARG and NLRP3 )