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New England Journal of Medicine, 384(11), 989-1002

Furthermore, the analog of -tocopherol, water-soluble vitamin E (Trolox), has been shown to reduce the hepatotoxicity of ATO while enhancing its anti-lymphoma effects

Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012

Handbook of Pharmaceutical Excipients

Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles

When oxygen molecules split into single atoms that have unpaired electrons, they become unstable free radicals that seek other atoms or molecules to bond to