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BJU International 108 (7), 11321138

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Curcumin can reduce hepatic succinate accumulation and prevented stellate cell activation via blocking succinate/HIF-1 signaling, which help to prevent liver fibrosis in mouse primary hepatic stellate cells [76]

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Metabolic dysregulation serves as a molecular bridge linking diabetes to pulmonary injury, where systemic imbalances in lipids, amino acids, and glucose generate pathogenic intermediates that travel to the lungs, triggering endothelial barrier breakdown, impaired repair, inflammation, and immune metabolic alterations (Figure 2)

We excluded 1 subject with Gilberts, 1 with already high baseline enzymes and 1 with HBV reactivation