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10.1186/s12967-024-05222-7 13

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FIGURE 3 The post-exercise blood lactate levels detected in rat models subjected to exhaustive swimming or treadmill tests showed that acute or short-term peptide supplementation (e.g., at dosages of 200600 mg/kg/day) was able to greatly reduce lactate accumulation when measured immediately post-exercise (61), interfering with reducing the oxidative injury of muscle tissue during maximal exercise

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Here we used such iPSC-derived complex liver organoids to assess the specific impact of ALGS-causing mutations on parenchymal and non-parenchymal liver cells, their role on bile duct formation and survival, and the interactions between signaling pathways suspected to play a role in ALGS pathophysiology