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It enhances their chemosensitivity to conventional therapies [230, 231]

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) Study #2 As I said, the second study was performed in 2011 by the same group, but with some improvements (IMHO)

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3.9 Summary Taken together, the available experimental evidence supports a hierarchical model of AP pathogenesis centered on the mitochondrial hub ( Figure 3 ), in which early pathogenic triggers, including toxic calcium signals, bile acid exposure, alcohol metabolites, hyperstimulation, and lipotoxic stress, initiate progressive remodeling of mitochondrial contact sites with the ER, lysosomes, the cytoskeleton, and other organelles

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