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Studies have confirmed that PDPN + CAFs can directly suppress ferroptosis via specific signaling axes to enhance tumor aggressiveness, while CAF-derived exosomes can modulate copper homeostasis by targeting the copper transporter ATP7A, thereby promoting cancer progression (Li et al., 2023d

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For example, Rickettsia has lost up to 20 metabolic pathways, including terpenoid biosynthesis, compared to its vacuole-residing relative Anaplasma