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In the treatment of PD, gene treatments primarily attempt to restore patients motor balance by elevating the stimulation of neurotrophic action in the brain [57]

Currently, many unresolved issues remain in the field of ferroptosis research

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Neurotoxicology 30, 977985

Ahmed, A, Colon, S, Dafflisio, GJ, Kothari, P, Uzoigwe, N, Zhou, A, Buchwald, J, Sharew, B, Glenn, C, Medvedovsky, S, Olivera, JA, Kramer, R, Colon, G, Tomasko, JM, Pereira, SJ, Antonoff, MB , Pelletier, M, Hameed, I