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The lower esophageal sphincter (LES) is a ring of muscle that acts as a valve between the esophagus and stomach

Interestingly, the elevated CHAC1 levels in TP53-mutant cells might represent an adaptive response, potentially compensating for defective ferroptosis pathways or preventing harmful GSH accumulation

T-T (tesamorelin to tesamorelin) refers to the group of patients who received tesamorelin for Weeks 0-26 and were re-randomized to tesamorelin for Weeks 26-52

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These studies were supported by grants from the Agence Nationale de la Recherche (ANR-2010-BLAN-1415-01, ANR12BVS10032), Institut National de la Sant et de la Recherche Mdicale, Centre National de la Recherche Scientifique, Universit de Montpellier, Biocampus, IPAM-BCM and Rgion Languedoc Roussillon to P-FM and PM