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In the presence of protein thiol groups, these quercetin-quinones will form toxic compounds that go on to exert pro-oxidant effects and cause damage throughout the body

In contrast, the GSH-treated samples appeared relatively normal, and their mitochondria were characterized by abundant, large, and clear cristae (Fig

While the heme may have prooxidant functions in large quantities, heme is constantly turned over and excreted from cells as bilirubin [81]

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Accordingly, cells have multiple sources of NADPH that are generated by cytosolic glycolytic and mitochondrial TCA-cycle intermediates

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