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Apoptosis and autophagocytic cell death are modulated by signaling pathways, whereas necrosis is classified as accidental cell death and is considered passive and not regulated by signaling pathways ( Researchers have long observed ferroptosis but classified it as one of the other types of cell death, and even dismissed it as meaningless ( + -independent cystine/glutamate antiporter system [system Xc()] and reduce the levels of the raw materials for GSH synthesis in cells

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YAP and TAZ interact with activated SMAD2/4 and SMAD3/4 complexes and increase their nuclear localization (Hiemer et al., 2014)

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