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Description

Methimazole is typically the first-line treatment due to its favorable dosing regimen and safety profile, while propylthiouracil is reserved for specific clinical scenarios such as pregnancy or severe toxicity

During the MD simulations, except the customize porphyrin residue and deLys residue, the other residues and water molecules in the systems were describe by the FF19SB force field 42 and TIP3P model 43