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Given the experimental mass differences, IsoNet deduces the atom difference thus a substructure of the unknown metabolite, and then a potential reaction taken place by matching against the reference reaction library

Notably, succinated secreted proteins showed minimal overlap with itaconated counterparts despite similar modification chemistries (Fig

Proc Natl Acad Sci U S A 101:37805, PMID: 15004285 Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD (2009) Novel role for glutathione S -transferase pi Regulator of protein S-glutathionylation following oxidative and nitrosative stress